Aluminum Adjuvant Linked to Gulf War Illness

By

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November 20, 2021

Aluminum Adjuvant Linked to Gulf War Illness Induces Motor Neuron Death in Mice

Abstract

Gulf War illness (GWI) affects a significant percentage of veterans of the 1991 conflict, but its origin remains unknown. Associated with some cases of GWI are increased incidences of amyotrophic lateral sclerosis and other neurological disorders. Whereas many environmental factors have been linked to GWI, the role of the anthrax vaccine has come under increasing scrutiny. Among the vaccine’s potentially toxic components are the adjuvants aluminum hydroxide and squalene.
To examine whether these compounds might contribute to neuronal deficits associated with GWI,
an animal model for examining the potential neurological impact of aluminum hydroxide, squalene, or aluminum hydroxide combined with squalene was developed. Young, male colony CD-1 mice were injected with the adjuvants at doses equivalent to those given to US military service personnel. All mice were subjected to a battery of motor and cognitive-behavioral tests over a 6-mo period post injections. Following sacrifice, central nervous system tissues were examined
using immunohistochemistry for evidence of inflammation and cell death. Behavioral testing showed motor deficits in the aluminum treatment group that expressed as a progressive decrease in strength measured by the wire-mesh hang test (final deficit at 24 wk; about 50%). Significant cognitive deficits in water-maze learning were observed in the combined aluminum and squalene group (4.3 errors per trial) compared with the controls (0.2 errors per trial) after 20 wk. Apoptotic
neurons were identified in aluminum-injected animals that showed significantly increased activated caspase-3 labeling in lumbar spinal cord (255%) and primary motor cortex (192%) compared with the controls. Aluminum-treated groups also showed significant motor neuron loss (35%) and increased numbers of astrocytes (350%) in the lumbar spinal cord. The findings suggest a possible role for the aluminum adjuvant in some neurological features associated with GWI and possibly
an additional role for the combination of adjuvants.

Full Article: https://link.springer.com/content/pdf/10.1385/NMM:9:1:83.pdf

ASIA Syndrome Published 2017

By

Kevin Thomson

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November 20, 2021

National Institutes of Health ASIA Syndrome — National Institutes of Health

Abstract

The autoimmune/inflammatory syndrome induced by adjuvants (ASIA), also known as Shoenfeld’s syndrome, encompasses several autoimmune conditions/phenomena that are induced following the exposure to substances with adjuvant activity. The disease spectrum is heterogeneous in respect to clinical presentation as well as severity of the clinical manifestations. Adjuvants are included in vaccination formulations for their immunogenic properties. Despite being generally well tolerated, safe and effective, some genetically predisposed individuals can develop generalized non-specific constitutional symptoms, autoantibody production, new onset, or worsening of disease presentation. In this review, we focus on the current knowledge presented in the literature on ASIA syndrome, increasing physician awareness about the basic concepts of ASIA syndrome and highlight the devastating amount of data accumulated in the last few years concerning the relationship between various adjuvants and autoimmunity.

Full Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046028/

PDF Form: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046028/pdf/MJR-28-2-64.pdf

Autoimmune/Inflammatory Syndrome Induced by Adjuvants

By

Kevin Thomson

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November 20, 2021

pubmed logo

Autoimmune/Inflammatory Syndrome Induced by Adjuvants (Shoenfeld’s Syndrome)

Abstract

An adjuvant is a substance that enhances the antigen-specific immune response, induces the release of inflammatory cytokines, and interacts with Toll-like receptors and the NALP3 inflammasome. The immunological consequence of these actions is to stimulate the innate and adaptive immune response. The activation of the immune system by adjuvants, a desirable effect, could trigger manifestations of autoimmunity or autoimmune disease. Recently, a new syndrome was introduced, autoimmune/inflammatory syndrome induced by adjuvants (ASIA), that includes postvaccination phenomena, macrophagic myofasciitis, Gulf War syndrome and siliconosis. This syndrome is characterized by nonspecific and specific manifestations of autoimmune disease. The main substances associated with ASIA are squalene (Gulf War syndrome), aluminum hydroxide (postvaccination phenomena, macrophagic myofasciitis) and silicone with siliconosis. Mineral oil, guaiacol and iodine gadital are also associated with ASIA. The following review describes the wide clinical spectrum and pathogenesis of ASIA including defined autoimmune diseases and nonspecific autoimmune manifestations, as well as the outlook of future research in this field.

Article: https://pubmed.ncbi.nlm.nih.gov/23557271/

Vaccine Immunoglobulin Antisera Adverse Reaction

By

Kevin Thomson

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November 20, 2021

Veteran Diagnosed with Vaccine Immunoglobulin Antisera Adverse Reaction

Vaccine Immunoglobulin Antisera Adverse Reaction

Full PDF Link: https://operationtruth.net/wp-content/uploads/articles/Problem%20List.pdf

Service Connection for Fibromyalgia as due to Anthrax Vaccination

By

Kevin Thomson

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November 20, 2021

Fibromyalgia Service Connection

Citation Nr: 1111676	
Decision Date: 03/23/11    Archive Date: 04/05/11

DOCKET NO.  07-05 127	)	DATE
	)
	)

On appeal from the
Department of Veterans Affairs Regional Office in Cleveland, Ohio


THE ISSUES

1. Entitlement to service connection for fibromyalgia, including as secondary to anthrax vaccinations.

2. Entitlement to service connection for dysthymic disorder, including as secondary to fibromyalgia.

Full Article: https://www.va.gov/vetapp11/files2/1111676.txt

Local Link: http://operationtruth.net/wp-content/uploads/articles/Fibro-Anthrax.pdf

Gulf War Veterans Medically Unexplained Illness

By

Kevin Thomson

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November 20, 2021

Gulf War Veterans Medically Unexplained Illness

Gulf War Veterans Medically Unexplained Illness VA refers to these illnesses as “chronic multisymptom illness” and “undiagnosed illnesses.”

Excerpt:

A prominent condition affecting Gulf War Veterans is a cluster of medically unexplained chronic symptoms that can include fatigue, headaches, joint pain, indigestion, insomnia, dizziness, respiratory disorders, and memory problems.

VA refers to these illnesses as “chronic multisymptom illness” and “undiagnosed illnesses.” We prefer not to use the term “Gulf War Syndrome” when referring to medically unexplained symptoms reported by Gulf War Veterans. Why? Because symptoms vary widely.

Full article: https://www.publichealth.va.gov/exposures/gulfwar/medically-unexplained-illness.asp

Vaccinations & Gulf War Veterans

By

Kevin Thomson

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November 20, 2021

Vaccinations & Gulf War Veterans

The following article on the VA’s website summarizes a lot of information in relation to Vaccinations & Gulf War Veterans, gulf war registry, unexplained illnesses, and more.

Excerpt:

VA and research organizations continue to evaluate possible causes of Gulf War Veterans’ chronic multisymptom illnesses, including vaccinations.

If you have health concerns, talk to your health care provider or contact your local VA Environmental Health Coordinator to help you get more information from a health care provider.

Full Link: https://www.publichealth.va.gov/exposures/gulfwar/sources/vaccinations.asp

Dr Meryl Nass research on GWI

By

Kevin Thomson

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November 10, 2021

Dr Meryl Nass research on GWI

Abstract:

The safety and efficacy of anthrax vaccine have not been
established, and the preponderance of the world’s literature
shows the vaccine is unsafe, and a contributor to Gulf War
Syndrome as acknowledged in the vaccine’s package insert

Full Article: https://operationtruth.net/wp-content/uploads/articles/MD%20Nass%20Research%20on%20GWS.pdf

BioThrax Package Insert

By

Kevin Thomson

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November 10, 2021

BioThrax Package Insert

BioThrax® (Anthrax Vaccine Adsorbed)
Emergent BioSolutions

Ever wonder what else was in the box along with the vaccine? The Department of Defense withheld the BioThrax Package Insert from troops. Below is the package insert available for download and viewing.

https://operationtruth.net/wp-content/uploads/articles/Biothrax-Package-Insert-2015.pdf

Anthrax Antigen PA63 In the Serum of Veterans with GWI

By

Kevin Thomson

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November 10, 2021