Mitochondrial Dysfunction and Chronic Disease

National Institutes of Health ASIA Syndrome
National Institutes of Health

Mitochondrial Dysfunction and Chronic Disease: Treatment With Natural Supplements

Garth L. Nicolson, PhD

Abstract

Loss of function in mitochondria, the key organelle responsible for cellular energy production, can result in the excess fatigue and other symptoms that are common complaints in almost every chronic disease. At the molecular level, a reduction in mitochondrial function occurs as a result of the following changes: (1) a loss of maintenance of the electrical and chemical transmembrane potential of the inner mitochondrial membrane, (2) alterations in the function of the electron transport chain, or (3) a reduction in the transport of critical metabolites into mitochondria. In turn, these changes result in a reduced efficiency of oxidative phosphorylation and a reduction in production of adenosine-5′-triphosphate (ATP). Several components of this system require routine replacement, and this need can be facilitated with natural supplements. Clinical trials have shown the utility of using oral replacement supplements, such as l-carnitine, alpha-lipoic acid (α-lipoic acid [1,2-dithiolane-3-pentanoic acid]), coenzyme Q10 (CoQ10 [ubiquinone]), reduced nicotinamide adenine dinucleotide (NADH), membrane phospholipids, and other supplements. Combinations of these supplements can reduce significantly the fatigue and other symptoms associated with chronic disease and can naturally restore mitochondrial function, even in long-term patients with intractable fatigue.

Full Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566449/

Local PDF: https://operationtruth.net/public_html/wp-content/uploads/articles/35-43.pdf

Kevin Thomson
Kevin is a former Navy Aviation Machinist Mate, and Former Department of Defense Systems Engineer. Besides being very mechanically inclined, he holds a Bachelors of Computer Science. Kevin is a vaccine injury veteran and spends his spare time helping Operation Truth with their mission.