Human Leukocyte Antigen (HLA) and Gulf War Illness (GWI)
Background
Gulf War Illness (GWI) is a multisystem disorder that has affected a substantial number of veterans who served in the 1990–91 Gulf War. The brain is prominently affected, as manifested by the presence of neurological, cognitive and mood symptoms. We reported previously on the protective role of six Human Leukocyte Antigen (HLA) alleles in GWI (Georgopoulos et al., 2016) and their association with regional brain function (James et al., 2016). More recently, we reported on the presence of subcortical brain atrophy in GWI (Christova et al., 2017) and discussed its possible relation to immune mechanisms. Here we focused on one of the six HLA GWI-protective HLA alleles, DRB1*13:02, which has been found to have a protective role in a broad range of autoimmune diseases (Furukawa et al., 2017), and tested its effects on brain volumes.
Full Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832612/
PDF Form: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832612/pdf/main.pdf
Take-Away: Veterans suffering from GWI should take a good amino acid supplemental blend and have a diet high in protein. Protein breaks down into amino acids. Veterans with GWI require much higher levels due to the illness constantly draining the reserve system in their bodies. For further information see our upcoming article on nutritional deficiency.