Diagnosis and Treatment of Chronic Mycoplasma Infections in Fibromyalgia and Chronic Fatigue Syndromes
Relationship to Gulf War Illness; Biomedical Therapy 1998
Mycoplasma infections are associated with several acute and chronic illnesses, including Pneumonia, Asthma, Rheumatoid Arthritis, Immunosuppression Diseases such as AIDS, Genitourinary Infections and Gulf War Illness (GWI). Using forensic Polymerase Chain Reaction blood samples from 132 Chronic Fatigue Syndrome (CFS) (Myalgic Encephalomyelitis ) and/or Fibromyalgia Syndrome (FMS) patients were investigated for the presence of mycoplasmal infections in blood leukocytes. CFS and FMS patients had completely overlapping signs and symptoms and were grouped for purposes of analysis. There was a significant difference between symptomatic CFS/FMS patients with positive mycoplasmal infections (~63%) and healthy positive controls (~9%) (P<0.001). We also examined the incidence of Mycoplasma fermentans infections in these CFS/FMS patients (~50%) and controls (0%)(P<0.001). The prevalence of mycoplasmal infections in female and male symptomatic patients was similar. Similar to GWI patients with mycoplasmal infections (~50%) and with similar signs and symptoms, mycoplasma-positive CFS/FMS patients respond to 6-week cycles of particular antibiotics: doxycycline, minocycline, ciprofloxacin, azithromycin and clarithromycin. Multiple cycles of these antibiotics plus nutritional support appear to be necessary for recovery.
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